View Danielle Graham’s profile on LinkedIn, the world's largest professional community. View Danielle Graham’s profile on LinkedIn, the world's largest professional community. Objective: The primary objective was to evaluate the safety, tolerability and pharmacokinetics of BIIB054, a human-derived monoclonal antibody that preferentially binds to aggregated forms of alpha-synuclein in patients with Parkinson’s disease (PD). Danielle has 1 job listed on their profile. See the complete profile on LinkedIn and discover Danielle’s connections and jobs at similar companies. Danielle has 2 jobs listed on their profile.

Search for more papers by this author. See the complete profile on LinkedIn and discover Danielle’s connections and jobs at similar companies. Danielle has 6 jobs listed on their profile.

See the complete profile on LinkedIn and discover Danielle’s connections and jobs at similar companies. Biogen, Cambridge, Massachusetts, USA. Biogen has also developed its own antibody, BIIB076, which is still in preclincial testing. Andreas Weihofen PhD. Background Alterations in neurofilament light chain (NfL), reflecting axonal damage, have been proposed as a biomarker for neurological disorders including Parkinson’s disease (PD). ... Biogen thanks the healthy volunteers and participants with Parkinson's disease who participated in this study. “Excited for @biogen director Dr. Danielle Graham's #CHIWPC17 prezo at 9:15 on 6/15: https://t.co/y68nhj75rR #biomarkers #clinicaldevelopment” Danielle Graham PhD. Background: Progression of PD is related to the spread of alpha-synuclein–containing intraneuronal inclusions (Lewy bodies and neurites).

Abstract Background Pathological and genetic evidence implicates toxic effects of aggregated α‐synuclein in the pathophysiology of neuronal dysfunction … In Vienna, Danielle Graham reported that BIIB076 recognizes both monomeric and fibrillar human and primate tau, binding to the protein with subnanomolar affinity. View Danielle Graham’s profile on LinkedIn, the world's largest professional community.

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